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The IGF axis is imperative for normal placental development and function. In the human placenta, IGF1R regulates the actions of IGFs and consequently placental growth. Some microRNAs (miRs) are also known to regulate human placental growth. miR-145 is known to exert its effects on human placental growth by targeting IGF1R. Whilst the expression of some components within the IGF axis are similar between mice and humans, murine expression and function of IGF regulatory miRs has ...

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ePoster

ea0059oc3.1 | Obesity & diabetes | SFEBES2018

Kisspeptin stimulates insulin secretion and modulates serum metabolites in humans

Izzi Engbeaya Chioma , Comninos Alexander N , Clarke Sophie A , Jomard Anne , Yang Lisa , Jones Sophie , Abbara Ali , Narayanaswamy Shakunthala , Chia Eng Pei , Papadopoulou Deborah , Prague Julia K , Bech Paul , Godsland Ian F , Bassett Paul , Sands Caroline , Camuzeaux Stephane , Gomez Romero Maria , Pearce Jake TM , Lewis Matthew R , Holmes Elaine , Nicholson Jeremy , Tan Tricia , Ratnasabapathy Risheka , Hu Ming , Carrat Gaelle , Piemonti Lorenzo , Bugliani Marco , Marchetti Piero , Johnson Paul R , Hughes Stephen J , James Shapiro AM , Rutter Guy A , Dhillo Waljit S

Background: Limited data exists on the hormonal mediators connecting metabolism and reproduction. Animal studies show that the reproductive hormone, kisspeptin, may also be important in metabolism. We investigated the effects of kisspeptin on human metabolism for the first time, to explore possible kisspeptin-mediated links between reproduction and metabolism.Methods: We performed intravenous glucose tolerance tests (IVGTTs) in 15 healthy men (age 25&#17...

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Endocrine Abstracts

miR-145 is associated with placental growth in mice

Kisspeptin stimulates insulin secretion and modulates serum metabolites in humans

BiosciAbstracts